General Information:

Id: 11,681 (click here to show other Interactions for entry)
Diseases: Metabolic
Mus musculus
male
ACE2 KO mouse; db/db mouse
INS-1 cells
article
Reference: Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354]

Interaction Information:

Comment ACE2 over-expression restored glucose-stimulated insulin secretion (GSIS) and mitochondrial membrane potential (MMP) in the presence of H2O2 in INS-1 cells.
Formal Description
Interaction-ID: 116221

gene/protein

ACE2

increases_activity of

process

positive regulation of mitochondrial membrane potential

the presence of H2O2 in INS-1 cells; ACE2 over-expression restored mitochondrial membrane potential (MMP)
Drugbank entries Show/Hide entries for ACE2