General Information:
Id: | 11,681 (click here to show other Interactions for entry) |
Diseases: |
Metabolic
|
Mus musculus | |
male | |
ACE2 KO mouse; db/db mouse | |
INS-1 cells | |
article | |
Reference: | Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354] |
Interaction Information:
Comment | ACE2 overexpression promotes calcium influx and mitochondrial oxidation, causing an increase in glucose-stimulated insulin secretion (GSIS) in islets. |
Formal Description Interaction-ID: 116149 |
gene/protein increases_activity of process mitochondrial oxidation |
Drugbank entries | Show/Hide entries for ACE2 |