CIDeRplusGeneral Information:
| Id: | 11,680 (click here to show other Interactions for entry) |
| Diseases: |
Metabolic
Muscular |
| Mus musculus | |
| ACE2 KO mouse | |
| undifferentiated mouse C2C12 myoblast cells | |
| article/cited | |
| Reference: | Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868] |
Interaction Information:
| Comment | ACE2 was overexpressed in the C2C12 cells to evaluate its role in lipid metabolism and ER stress by RT-PCR analysis in vitro. Firstly, ACE2 has been proved to be indeed overexpressed after the adenoviruses infect. Secondly, the mRNA levels of fatty acid oxidation-related genes, PPARalpha, PPARgamma, and CPT1A were increased, and little change was observed in PGC-1alpha and MCAD in ACE2-overexpressing C2C12 cells. The results showed that the overexpression of ACE2 significantly improved fatty acid oxidation and ER stress. |
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Formal Description Interaction-ID: 116109 |
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| Drugbank entries | Show/Hide entries for ACE2 or CPT1A |