General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment Activation of ACE2 can ameliorate ER stress and mitochondrial function, which slightly accompanied by reduced TG content and down-regulated the expression of skeletal muscle lipogenic proteins in the db/db mice.
Formal Description
Interaction-ID: 116080

gene/protein

ACE2

decreases_activity of

process

response to endoplasmic reticulum stress

decreasing ER stress via activation of ACE2
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 improves skeletal muscle lipid metabolism in vitro and in vivo.
Formal Description
Interaction-ID: 116081

gene/protein

ACE2

increases_activity of

process

lipid metabolic process

in mouse skeletal muscle in vivo and in vitro
Drugbank entries Show/Hide entries for ACE2
Comment Endogenous ACE2 improved lipid metabolism through the IKKbeta/NFkappaB/IRS-1 pathway in skeletal muscle.
Formal Description
Interaction-ID: 116082

gene/protein

ACE2

increases_activity of

process

IKBKB/NFKB1/IRS1 signaling

in mouse skeletal muscle in vivo and in vitro; improving the lipid metabolism
Drugbank entries Show/Hide entries for ACE2
Comment Activation of ACE2 can ameliorate ER stress and mitochondrial function, which slightly accompanied by reduced TG content and down-regulated the expression of skeletal muscle lipogenic proteins in the db/db mice.
Formal Description
Interaction-ID: 116085

gene/protein

ACE2

increases_activity of

cellular component

mitochondrion

ameliorating mitochondrial function via activation of ACE2
Drugbank entries Show/Hide entries for ACE2
Comment Activation of ACE2 can ameliorate ER stress and mitochondrial function, which slightly accompanied by reduced triglyceride (TG) content and down-regulated the expression of skeletal muscle lipogenic proteins in the db/db mice.
Formal Description
Interaction-ID: 116086

gene/protein

ACE2

decreases_quantity of

drug/chemical compound

Triacylglycerol

in db/db mice; slightly reducing TG content via activation of ACE2
Drugbank entries Show/Hide entries for ACE2
Comment Activation of ACE2 can ameliorate ER stress and mitochondrial function, which slightly accompanied by reduced triglyceride (TG) content and down-regulated the expression of skeletal muscle lipogenic proteins in the db/db mice.
Formal Description
Interaction-ID: 116087

gene/protein

ACE2

decreases_expression of

gene/protein

lipogenic proteins

in db/db mice; down-regulated expression of skeletal muscle lipogenic proteins via activation of ACE2
Drugbank entries Show/Hide entries for ACE2
Comment The ACE2 mRNA levels were indeed reduced in the skeletal muscle of the ACE2 KO mice. They exhibited breakage of fibers and disorder of morphology. The skeletal muscle TG content was significantly higher in ACE2 KO mice than in WT mice.
Formal Description
Interaction-ID: 116098

organism model

ACE2 KO mouse

decreases_expression of

gene/protein

ACE2

in the skeletal muscle of the ACE2 KO mice; concerning ACE2 mRNA content
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 was overexpressed in the C2C12 cells to evaluate its role in lipid metabolism and ER stress by RT-PCR analysis in vitro. Firstly, ACE2 has been proved to be indeed overexpressed after the adenoviruses infect. Secondly, the mRNA levels of fatty acid oxidation-related genes, PPARalpha, PPARgamma, and CPT1A were increased, and little change was observed in PGC-1alpha and MCAD in ACE2-overexpressing C2C12 cells. The results showed that the overexpression of ACE2 significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116107

gene/protein

ACE2

increases_expression of

gene/protein

PPARA

in ACE2-overexpressing C2C12 cells; concerning PPARA mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
Drugbank entries Show/Hide entries for ACE2 or PPARA
Comment ACE2 was overexpressed in the C2C12 cells to evaluate its role in lipid metabolism and ER stress by RT-PCR analysis in vitro. Firstly, ACE2 has been proved to be indeed overexpressed after the adenoviruses infect. Secondly, the mRNA levels of fatty acid oxidation-related genes, PPARalpha, PPARgamma, and CPT1A were increased, and little change was observed in PGC-1alpha and MCAD in ACE2-overexpressing C2C12 cells. The results showed that the overexpression of ACE2 significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116108

gene/protein

ACE2

increases_expression of

gene/protein

PPARG

in ACE2-overexpressing C2C12 cells; concerning PPARG mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
Drugbank entries Show/Hide entries for ACE2 or PPARG
Comment ACE2 was overexpressed in the C2C12 cells to evaluate its role in lipid metabolism and ER stress by RT-PCR analysis in vitro. Firstly, ACE2 has been proved to be indeed overexpressed after the adenoviruses infect. Secondly, the mRNA levels of fatty acid oxidation-related genes, PPARalpha, PPARgamma, and CPT1A were increased, and little change was observed in PGC-1alpha and MCAD in ACE2-overexpressing C2C12 cells. The results showed that the overexpression of ACE2 significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116109

gene/protein

ACE2

increases_expression of

gene/protein

CPT1A

in ACE2-overexpressing C2C12 cells; concerning CPT1A mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
Drugbank entries Show/Hide entries for ACE2 or CPT1A
Comment The results showed that the overexpression of ACE2 in the C2C12 cells significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116110

gene/protein

ACE2

increases_activity of

process

fatty acid oxidation

in ACE2-overexpressing C2C12 cells
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 was first reported to play a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function.
Formal Description
Interaction-ID: 116113

gene/protein

ACE2

increases_activity of

cellular component

endoplasmic reticulum

playing a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function
Drugbank entries Show/Hide entries for ACE2
Comment The results showed that the overexpression of ACE2 in the C2C12 cells significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116114

gene/protein

ACE2

decreases_activity of

process

response to endoplasmic reticulum stress

in ACE2-overexpressing C2C12 cells
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 was first reported to play a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function.
Formal Description
Interaction-ID: 116115

gene/protein

ACE2

increases_activity of

cellular component

mitochondrion

playing a notable role on intramuscular fat regulation by improving endoplasmic reticulum and mitochondrial function
Drugbank entries Show/Hide entries for ACE2
Comment The protein levels of lipogenesis proteins ACCalpha and SREBP-1C increased in the ACE2 KO mice, and decreased in the ACE2-overexpressing db/db mice. These results suggested that ACE2 may regulate intramuscular fat accumulate in mice.
Formal Description
Interaction-ID: 116142

gene/protein

ACE2

decreases_quantity of

gene/protein

ACACA

in ACE2-overexpressing db/db mice
Drugbank entries Show/Hide entries for ACE2 or ACACA
Comment The protein levels of lipogenesis proteins ACCalpha and SREBP-1C increased in the ACE2 KO mice, and decreased in the ACE2-overexpressing db/db mice. These results suggested that ACE2 may regulate intramuscular fat accumulate in mice.
Formal Description
Interaction-ID: 116143

gene/protein

ACE2

decreases_quantity of

mRNA/protein variant

SREBF1

in ACE2-overexpressing db/db mice
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 deficiency in vivo displayed lipid accumulation, ER stress and mitochondrial dysfunction in skeletal muscle.
Formal Description
Interaction-ID: 116929

gene/protein

ACE2

decreases_activity of

phenotype

abnormal mitochondrial physiology

reasoned via ACE2 KO mice in skeletal muscles
Drugbank entries Show/Hide entries for ACE2
Comment The protein levels of GRP78, eIF2alpha, ATF4, and CHOP were all significantly up-regulated in the skeletal muscle of the ACE2 KO mice.
Formal Description
Interaction-ID: 120293

gene/protein

ACE2

decreases_quantity of

gene/protein

HSPA5

in the skeletal muscle of ACE2 KO mice; GRP78 protein was up-regulated
Drugbank entries Show/Hide entries for ACE2 or HSPA5