CIDeRplusGeneral Information:
| Id: | 116 |
| Diseases: |
Alzheimer disease
- [OMIM]
|
| Homo sapiens | |
| BTO:0000007 HEK-293 cell | |
| article | |
| Reference: | Alessi DR et al.(1996) Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15: 6541-6551 [PMID: 8978681] |
Interaction Information:
| Comment | After transfection into 293 cells AKT1 was activated 20- and 50-fold in response to insulin and IGF-1 respectively. |
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Formal Description Interaction-ID: 389 |
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| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | After transfection into 293 cells AKT1 was activated 20- and 50-fold in response to insulin and IGF-1 respectively. |
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Formal Description Interaction-ID: 391 |
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| Drugbank entries | Show/Hide entries for IGF1 or AKT1 |
| Comment | The activation of AKT1 was accompanied by its phosphorylation at Thr308 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin. |
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Formal Description Interaction-ID: 393 |
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| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | The activation of AKT1 was accompanied by its phosphorylation at Thr308 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin. |
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Formal Description Interaction-ID: 394 |
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| Drugbank entries | Show/Hide entries for IGF1 or AKT1 |
| Comment | Wortmannin is a phosphatidylinositol 3-kinase inhibitor. |
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Formal Description Interaction-ID: 397 |
drug/chemical compound decreases_phosphorylation of gene/protein |
| Drugbank entries | Show/Hide entries for AKT1 |
| Comment | MAPKAP kinase-2 phosphorylates Ser473 of AKT1 causing partial activation. |
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Formal Description Interaction-ID: 401 |
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| Drugbank entries | Show/Hide entries for MAPKAPK2 or AKT1 |
| Comment | MAPKAP kinase-2 phosphorylates Ser473 of AKT1 causing partial activation. |
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Formal Description Interaction-ID: 404 |
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| Drugbank entries | Show/Hide entries for MAPKAPK2 or AKT1 |
| Comment | AKT1-Phosphorylation of Thr308 is not dependent on AKT1-phosphorylation of Ser473 or vice versa in 293 cells. |
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Formal Description Interaction-ID: 405 |
protein modification AKT1-phosThr308 NOT affects_phosphorylation of protein modification AKT1-phosSer473 |
| Comment | AKT1-Phosphorylation of Thr308 is not dependent on AKT1-phosphorylation of Ser473 or vice versa in 293 cells. |
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Formal Description Interaction-ID: 12845 |
protein modification AKT1-phosSer473 NOT affects_phosphorylation of protein modification AKT1-phosThr308 |
| Comment | Wortmannin is a phosphatidylinositol 3-kinase inhibitor. |
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Formal Description Interaction-ID: 12850 |
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| Comment | The activation of AKT1 was accompanied by its phosphorylation at Thr308 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin. |
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Formal Description Interaction-ID: 12851 |
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| Comment | The activation of AKT1 was accompanied by its phosphorylation at Thr308 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin. |
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Formal Description Interaction-ID: 12852 |
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| Comment | Wortmannin is a phosphatidylinositol 3-kinase inhibitor. |
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Formal Description Interaction-ID: 139390 |
drug/chemical compound decreases_activity of |