General Information:

Id: 113 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0001760 myotubes (L6)
article
Reference: Alessi DR et al.(1996) Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15: 6541-6551 [PMID: 8978681]

Interaction Information:

Comment Insulin activated endogenous protein kinase Ba (also known as RAC/Akt kinase) activity. The activation of AKT1 was accompanied by its phosphorylation at Thr3O8 and Ser473 and, like activation, phosphorylation of both of these residues was prevented by the phosphatidylinositol 3-kinase inhibitor wortmannin.
Formal Description
Interaction-ID: 395

complex/PPI

Insulin

increases_phosphorylation of

gene/protein

AKT1

at Thr308 and Ser473
Drugbank entries Show/Hide entries for AKT1