General Information:

Id: 1,136
Diseases: Epilepsy
Status epilepticus
Rattus norvegicus
Sprague-Dawley rats
BTO:0000601 hippocampus
article
Reference: Nicoletti JN et al.(2008) Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience 151: 232-241 [PMID: 18065154]

Interaction Information:

Comment The expression of inflammatory-related growth factor VEGF was increased after pilocarpine-induced status epilepticus.
Formal Description
Interaction-ID: 7381

drug/chemical compound

Pilocarpine

increases_activity of

Drugbank entries Show/Hide entries for Pilocarpine
Comment The expression of inflammatory-related growth factor VEGF was increased after pilocarpine-induced status epilepticus.
Formal Description
Interaction-ID: 7387

increases_activity of

disease

Status epilepticus

Comment The expression of inflammatory-related growth factor VEGF was increased after pilocarpine-induced status epilepticus.
Formal Description
Interaction-ID: 7388

disease

Status epilepticus

increases_expression of

gene/protein

VEGFA

Drugbank entries Show/Hide entries for VEGFA
Comment Animals infused with inflammatory-related growth factor VEGF appeared to have less neuronal loss and fewer neurons with pyknotic profiles. VEGF had significantly higher neuronal densities than animals given pilocarpine and infused with PBS or control proteins.
Formal Description
Interaction-ID: 7401

gene/protein

VEGFA

decreases_activity of

process

neuron death

Drugbank entries Show/Hide entries for VEGFA
Comment Animals infused with inflammatory-related growth factor VEGF appeared to have less neuronal loss and fewer neurons with pyknotic profiles. VEGF had significantly higher neuronal densities than animals given pilocarpine and infused with PBS or control proteins.
Formal Description
Interaction-ID: 7403

gene/protein

VEGFA

increases_activity of

Drugbank entries Show/Hide entries for VEGFA