General Information:

Id: 1,107 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Candore G et al.(2010) Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications Rejuvenation Res 13: 301-313 [PMID: 20462385]

Interaction Information:

Comment The APOE4 allele is a genetic variant that has been clearly associated with increased risk of late-onset AD.
Formal Description
Interaction-ID: 7243

gene/protein mutant

APOE (isoform E4)

increases_activity of

disease

Alzheimer disease

Comment The APO-epsilon4 allele accelerates amyloid deposition and promotes Abeta aggregation in cholesterol-rich lipid rafts, enhancing aggregation into senile plaques.
Formal Description
Interaction-ID: 7344

gene/protein mutant

APOE (isoform E4)

increases_quantity of

phenotype

amyloid beta deposits