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Field	Query

	Field	Term

General Information:

Id:	1,106
Diseases:	Schizophrenia - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0002807 prefrontal cortex; BTO:0000484 frontal lobe
Publication type:	article
Reference:	Tan HY et al.(2008) Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans J. Clin. Invest. 118: 2200-2208 [PMID: 18497887]

Interaction Information:

Comment	The A allelle of the AKT1 SNP rs1130233 is associated with cognitive deficits in IQ and executive function.
Formal Description Interaction-ID: 7051	SNP AKT1 rs1130233 decreases_activity of process cognition

Comment	The carriers of AKT1 rs1130233 A allele had reduced grey matter volumes of the basal ganglia and the right PFC.
Formal Description Interaction-ID: 7057	SNP AKT1 rs1130233 decreases_quantity of tissue/cell line cerebral gray matter

Comment	The functional polymorphism (Val158Met) of the COMT gene leads to lower dopamine level.
Formal Description Interaction-ID: 7058	SNP COMT rs4680 decreases_quantity of drug/chemical compound Dopamine
Drugbank entries	Show/Hide entries for
Drugbank DB00988	Dopamine agonist DRD1
Drugbank DB00988	Dopamine ligand DBH
Drugbank DB00988	Dopamine agonist DRD5
Drugbank DB00988	Dopamine agonist DRD2
Drugbank DB00988	Dopamine agonist DRD3
Drugbank DB00988	Dopamine agonist DRD4
Drugbank DB00988	Dopamine inducer SLC6A3

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