General Information:

Id: 1,082
Diseases: Parkinson disease
Mus musculus
BTO:0001976 Neuro-2a cell
article
Reference: Saeed U et al.(2010) DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death Antioxid. Redox Signal. 13: 127-144 [PMID: 20014998]

Interaction Information:

Comment Downregulation of Grx1 causes post-translational decrease of DJ-1 whereas its mRNA levels are unaltered.
Formal Description
Interaction-ID: 6854

gene/protein

GLRX

NOT affects_expression of

gene/protein

PARK7

Drugbank entries Show/Hide entries for GLRX or PARK7
Comment Downregulation of Grx1 causes post-translational decrease of DJ-1 whereas its mRNA levels are unaltered.
Formal Description
Interaction-ID: 6855

gene/protein

GLRX

affects_quantity of

gene/protein

PARK7

Drugbank entries Show/Hide entries for GLRX or PARK7
Comment Grx1 knockdown resulted in increased generation of ROS.
Formal Description
Interaction-ID: 6856

gene/protein

GLRX

affects_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for GLRX
Comment Silencing of GRX1 generates oxidative stress in cells.
Formal Description
Interaction-ID: 6859

gene/protein

GLRX

affects_activity of

process

response to oxidative stress

Drugbank entries Show/Hide entries for GLRX
Comment DJ-1 levels are enriched in mitochondrial fraction of cells with Grx1 knockdown.
Formal Description
Interaction-ID: 6861

gene/protein

GLRX

affects transport of

gene/protein

PARK7

into mitochondria
Drugbank entries Show/Hide entries for GLRX or PARK7
Comment Downregulation of Grx1 leads to loss of nuclear DJ-1 and translocation of Daxx from nucleus to cytosol.
Formal Description
Interaction-ID: 6863

gene/protein

GLRX

affects transport of

gene/protein

DAXX

from nucleus into cytosol
Drugbank entries Show/Hide entries for GLRX
Comment Daxx translocates to the cytosol in response to oxidative stimulus, thereby propagating the cell death cascade.
Formal Description
Interaction-ID: 6864

gene/protein

DAXX

increases_activity of

process

neuron death

after translocation of DAXX from the nucleus to the cytosol
Comment Overexpressed WT human DJ-1 prevents Daxx translocation and abolishes cytotoxicity.
Formal Description
Interaction-ID: 6865

gene/protein

PARK7

decreases transport of

gene/protein

DAXX

from nucleus into cytosol
Drugbank entries Show/Hide entries for PARK7
Comment Overexpressed WT human DJ-1 prevents Daxx translocation and abolishes cytotoxicity.
Formal Description
Interaction-ID: 6866

gene/protein

PARK7

decreases_activity of

gene/protein

DAXX

via retention of DAXX within the nucleus
Drugbank entries Show/Hide entries for PARK7
Comment Thiol groups of DJ-1 are oxidatively modified in response to Grx1 knockdown and oxidatively modified DJ-1 is degraded rapidly. Grx1 downregulation did not affect levels of DJ-1 mutants.
Formal Description
Interaction-ID: 6867

gene/protein

GLRX

affects_quantity of

gene/protein

PARK7

via oxidative modification and subsequent degradation of DJ-1 in response to Grx1 knockdown
Drugbank entries Show/Hide entries for GLRX or PARK7
Comment Grx1 downregulation did not affect levels of DJ-1 mutants unlike that observed with wild-type DJ-1, suggesting that cysteine residues were involved mechanistically in the loss of DJ-1.
Formal Description
Interaction-ID: 6868

gene/protein

GLRX

NOT affects_quantity of

gene/protein mutant

PARK7-p.C53A

Drugbank entries Show/Hide entries for GLRX
Comment Grx1 downregulation did not affect levels of DJ-1 mutants unlike that observed with wild-type DJ-1, suggesting that cysteine residues were involved mechanistically in the loss of DJ-1.
Formal Description
Interaction-ID: 6869

gene/protein

GLRX

NOT affects_quantity of

gene/protein mutant

PARK7-p.C106A

Drugbank entries Show/Hide entries for GLRX
Comment Grx1 downregulation did not affect levels of DJ-1 mutants unlike that observed with wild-type DJ-1, suggesting that cysteine residues were involved mechanistically in the loss of DJ-1.
Formal Description
Interaction-ID: 6870

gene/protein

GLRX

NOT affects_quantity of

gene/protein mutant

PARK7-p.L166P

Drugbank entries Show/Hide entries for GLRX