CIDeRplusGeneral Information:
| Id: | 1,074 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mammalia | |
| BTO:0001976 Neuro-2a cell | |
| article | |
| Reference: | Zhong Z et al.(2009) Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J. Clin. Invest. 119: 3437-3449 [PMID: 19841542] |
Interaction Information:
| Comment | Neuroprotection by APC reduces hemoglobin and ROS toxicity. Addition of mutant 5A-APC (having 10% of the anticoagulant activity of WT-APC but retaining normal cytoprotective activity) at concentrations comparable to therapeutically effective levels in SOD1G93A mice abolished hemoglobin (Hb)-induced toxicity and lowered detectable levels of ROS. S360A-APC was ineffective in improving cell survival or preventing ROS generation. |
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Formal Description Interaction-ID: 6794 |
gene/protein mutant NOT decreases_quantity of drug/chemical compound Reactive oxygen species |