General Information:

Id: 1,070
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Lev N et al.(2009) DJ-1 protects against dopamine toxicity. J Neural Transm 116: 151-160 [PMID: 18974921]

Interaction Information:

Comment Exposure of neuroblastoma cells to increasing doses of dopamine resulted in decreased metabolic activity and cell death. Overexpression of DJ-1 protected cells from the toxic effect of dopamine, while decreasing DJ-1 levels resulted in increased vulnerability to dopamine exposure.
Formal Description
Interaction-ID: 6739

drug/chemical compound

Dopamine

increases_activity of

process

neuron death

Drugbank entries Show/Hide entries for Dopamine
Comment Exposure of neuroblastoma cells to increasing doses of dopamine resulted in decreased metabolic activity and cell death. Overexpression of DJ-1 protected cells from the toxic effect of dopamine, while decreasing DJ-1 levels resulted in increased vulnerability to dopamine exposure.
Formal Description
Interaction-ID: 6740

gene/protein

PARK7

decreases_activity of

process

neuron death

induced by dopamine
Drugbank entries Show/Hide entries for PARK7
Comment Exposure of cells to dopamine caused increased intracellular ROS levels. Overexpression of DJ-1 significantly reduced intracellular ROS accumulation after dopamine exposure.
Formal Description
Interaction-ID: 6742

drug/chemical compound

Dopamine

increases_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for Dopamine
Comment Exposure of cells to dopamine caused increased intracellular ROS levels. Overexpression of DJ-1 significantly reduced intracellular ROS accumulation after dopamine exposure.
Formal Description
Interaction-ID: 6743

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

Reactive oxygen species

Drugbank entries Show/Hide entries for PARK7
Comment Dopamine exposure leads to ROS-mediated upregulation of DJ-1.
Formal Description
Interaction-ID: 6744

drug/chemical compound

Reactive oxygen species

increases_quantity of

gene/protein

PARK7

Drugbank entries Show/Hide entries for PARK7
Comment Dopamine exposure leads to ROS-mediated upregulation of DJ-1.
Formal Description
Interaction-ID: 6745

drug/chemical compound

Dopamine

increases_quantity of

gene/protein

PARK7

by increasing ROS level
Drugbank entries Show/Hide entries for Dopamine or PARK7
Comment Dopamine exposure led to a rapid phosphorylation of ERK 1 and 2.
Formal Description
Interaction-ID: 6746

drug/chemical compound

Dopamine

increases_phosphorylation of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for Dopamine or MAPK3
Comment Dopamine exposure led to a rapid phosphorylation of ERK 1 and 2.
Formal Description
Interaction-ID: 6747

drug/chemical compound

Dopamine

increases_phosphorylation of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for Dopamine or MAPK1
Comment ERK1, 2 activation preceded upregulation of DJ-1 mRNA.
Formal Description
Interaction-ID: 6748

gene/protein

MAPK3

increases_expression of

gene/protein

PARK7

Drugbank entries Show/Hide entries for MAPK3 or PARK7
Comment ERK1, 2 activation preceded upregulation of DJ-1 mRNA.
Formal Description
Interaction-ID: 6749

gene/protein

MAPK1

increases_expression of

gene/protein

PARK7

Drugbank entries Show/Hide entries for MAPK1 or PARK7
Comment ERK1, 2 activation preceded upregulation of DJ-1 mRNA.
Formal Description
Interaction-ID: 6750

process

ERK1 and ERK2 cascade

increases_expression of

gene/protein

PARK7

Drugbank entries Show/Hide entries for PARK7
Comment Dopamine exposure led to a rapid phosphorylation of ERK 1 and 2.
Formal Description
Interaction-ID: 6751

drug/chemical compound

Dopamine

increases_activity of

process

ERK1 and ERK2 cascade

Drugbank entries Show/Hide entries for Dopamine