General Information:

Id: 1,068
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0003037 HT-22 cell
article
Reference: Sun KH et al.(2008) Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction J. Neurochem. 107: 265-278 [PMID: 18691386]

Interaction Information:

Comment Peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) were identified as direct substrates of Cdk5 from mouse brain lysates.
Formal Description
Interaction-ID: 6726

gene/protein

CDK5

affects_phosphorylation of

gene/protein

PRDX1

mouse brain lysate
Drugbank entries Show/Hide entries for CDK5
Comment Peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) were identified as direct substrates of Cdk5 from mouse brain lysates.
Formal Description
Interaction-ID: 6732

gene/protein

CDK5

affects_phosphorylation of

gene/protein

PRDX2

mouse brain lysate
Drugbank entries Show/Hide entries for CDK5 or PRDX2
Comment Prx-I and Prx-II lose their peroxidase functions upon phosphorylation by Cdk5/p25.
Formal Description
Interaction-ID: 6737

gene/protein

CDK5

decreases_activity of

gene/protein

PRDX1

Drugbank entries Show/Hide entries for CDK5
Comment Prx-I and Prx-II lose their peroxidase functions upon phosphorylation by Cdk5/p25.
Formal Description
Interaction-ID: 6738

complex/PPI

CDK5-p25 complex

decreases_activity of

gene/protein

PRDX2

Drugbank entries Show/Hide entries for PRDX2
Comment Prx-I and Prx-II lose their peroxidase functions upon phosphorylation by Cdk5/p25.
Formal Description
Interaction-ID: 6784

complex/PPI

CDK5-p25 complex

affects_phosphorylation of

gene/protein

PRDX2

Drugbank entries Show/Hide entries for PRDX2
Comment Prx-I and Prx-II lose their peroxidase functions upon phosphorylation by Cdk5/p25.
Formal Description
Interaction-ID: 6785

complex/PPI

CDK5-p25 complex

decreases_activity of

gene/protein

PRDX1

Comment Prx-I and Prx-II lose their peroxidase functions upon phosphorylation by Cdk5/p25.
Formal Description
Interaction-ID: 6786

complex/PPI

CDK5-p25 complex

affects_phosphorylation of

gene/protein

PRDX1

Comment Cdk5 is a key enzyme that promotes ROS accumulation upon glutamate stimulation. Inhibition of Cdk5 leads to reduction of ROS accumulation in primary neurons upon Abeta and glutamate stimulation.
Formal Description
Interaction-ID: 6840

gene/protein

CDK5

affects_quantity of

drug/chemical compound

Reactive oxygen species

depending of glutamate stimulation
Drugbank entries Show/Hide entries for CDK5
Comment Glutamate stimulation increased ROS levels.
Formal Description
Interaction-ID: 6841

drug/chemical compound

Glutamate

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Abeta(25-35) treatment resulted in more than 2.5-fold increase in ROS levels in primary cortical cells, which was Cdk5-dependent.
Formal Description
Interaction-ID: 6843

gene/protein

Amyloid beta peptide (25-35)

increases_quantity of

drug/chemical compound

Reactive oxygen species

2.5-fold increase in ROS levels, Cdk5-dependent
Comment Cdk5 initiates oxidative stress and thus may be an upstream regulator of mitochondrial damage.
Formal Description
Interaction-ID: 6844

gene/protein

CDK5

affects_activity of

process

response to oxidative stress

Drugbank entries Show/Hide entries for CDK5
Comment Sole activation of Cdk5 is not enough to cause significant mitochondrial damage.
Formal Description
Interaction-ID: 6845

gene/protein

CDK5

NOT affects_activity of

phenotype

abnormal mitochondrial physiology

Drugbank entries Show/Hide entries for CDK5
Comment Cdk5 initiates oxidative stress and thus may be an upstream regulator of mitochondrial damage.
Formal Description
Interaction-ID: 20823

gene/protein

CDK5

increases_activity of

process

response to oxidative stress

Drugbank entries Show/Hide entries for CDK5