CIDeRplusGeneral Information:
| Id: | 1,005 |
| Diseases: |
Parkinson disease
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| Rattus norvegicus | |
| BTO:0002393 N-27 cell | |
| article | |
| Reference: | Zhou W and Freed CR(2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity J. Biol. Chem. 280 [PMID: 16227205] |
Interaction Information:
| Comment | Overexpression of human DJ-1 protects N27 cells from oxidative stress induced by H2O2 or 6-OHDA. |
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Formal Description Interaction-ID: 6266 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Overexpression of human DJ-1 protects N27 cells from oxidative stress induced by H2O2 or 6-OHDA. |
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Formal Description Interaction-ID: 6267 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Overexpression of human DJ-1 protects N27 cells from oxidative stress induced by H2O2 or 6-OHDA. |
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Formal Description Interaction-ID: 6268 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Overexpression of human DJ-1 protects N27 cells from oxidative stress induced by H2O2 or 6-OHDA. |
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Formal Description Interaction-ID: 6269 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Overexpression of human DJ-1 protects N27 cells from oxidative stress induced by H2O2 or 6-OHDA. |
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Formal Description Interaction-ID: 6270 |
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| Comment | Overexpression of WT DJ-1 did not protect N27 cells against cell toxicity caused by the proteasome inhibitor lactacystin, indicating that the action of DJ-1 has some metabolic specificity. |
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Formal Description Interaction-ID: 6271 |
drug/chemical compound Lactacystin decreases_activity of |
| Comment | Overexpression of WT DJ-1 did not protect N27 cells against cell toxicity caused by the proteasome inhibitor lactacystin, indicating that the action of DJ-1 has some metabolic specificity. |
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Formal Description Interaction-ID: 6272 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | DJ-1 protects against oxidative damage by increasing intracellular glutathion levels. |
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Formal Description Interaction-ID: 6277 |
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| Drugbank entries | Show/Hide entries for PARK7 or Glutathione |
| Comment | WT DJ-1 significantly increased GCL enzymatic activity under oxidative stress, whereas GS enzymatic activity was not changed. |
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Formal Description Interaction-ID: 6278 |
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| Drugbank entries | Show/Hide entries for PARK7 or GCLC |
| Comment | WT DJ-1 significantly increased GCL enzymatic activity under oxidative stress, whereas GS enzymatic activity was not changed. |
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Formal Description Interaction-ID: 6279 |
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| Drugbank entries | Show/Hide entries for PARK7 or GSS |
| Comment | WT DJ-1 significantly increased mRNA levels for GCL after oxidative stress. The GS mRNA levels were not changed after H2O2 exposure. |
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Formal Description Interaction-ID: 6280 |
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| Drugbank entries | Show/Hide entries for PARK7 or GCLC |
| Comment | WT DJ-1 significantly increased mRNA levels for GCL after oxidative stress. The GS mRNA levels were not changed after H2O2 exposure. |
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Formal Description Interaction-ID: 6281 |
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| Drugbank entries | Show/Hide entries for PARK7 or GSS |
| Comment | DJ-1 significantly reduced total cellular ROS levels after oxidative stress compared with control. The L166P DJ-1 had no effect on ROS. |
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Formal Description Interaction-ID: 6282 |
gene/protein decreases_quantity of drug/chemical compound Reactive oxygen species |
| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | DJ-1 significantly reduced total cellular ROS levels after oxidative stress compared with control. The L166P DJ-1 had no effect on ROS. |
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Formal Description Interaction-ID: 6283 |
gene/protein mutant NOT decreases_quantity of drug/chemical compound Reactive oxygen species |
| Comment | DJ-1 significantly reduced protein oxidation compared with control, whereas 166P DJ-1 showed no protection against protein oxidation. |
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Formal Description Interaction-ID: 6288 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | DJ-1 significantly reduced protein oxidation compared with control, whereas 166P DJ-1 showed no protection against protein oxidation. |
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Formal Description Interaction-ID: 6289 |
gene/protein mutant NOT decreases_activity of process |
| Comment | DJ-1 inhibits aggregation of A35T alpha-synuclein and alpha-synuclein induced apoptosis. |
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Formal Description Interaction-ID: 6290 |
gene/protein decreases_quantity of phenotype |
| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | DJ-1 inhibits aggregation of A35T alpha-synuclein and alpha-synuclein induced apoptosis. |
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Formal Description Interaction-ID: 6292 |
gene/protein decreases_activity of process |
| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Hsp70 has been demonstrated to block alpha-synuclein aggregation and toxicity. |
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Formal Description Interaction-ID: 6293 |
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| Comment | Hsp70 protein was significantly increased in DJ-1 transduced cells. |
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Formal Description Interaction-ID: 6294 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Levels for Hsp70 mRNA were significantly increased in cells treated with WT DJ-1 and to a lesser extent, increased in A53T alpha-synuclein alone. The data suggest that DJ-1 inhibits A53T alpha-synuclein aggregation by increasing HSP70. |
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Formal Description Interaction-ID: 6295 |
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| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Levels for Hsp70 mRNA were significantly increased in cells treated with WT DJ-1 and to a lesser extent, increased in A53T alpha-synuclein alone. The data suggest that DJ-1 inhibits A53T alpha-synuclein aggregation by increasing HSP70. |
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Formal Description Interaction-ID: 6296 |
gene/protein decreases_quantity of phenotype |
| Drugbank entries | Show/Hide entries for PARK7 |
| Comment | Mutations in the DJ-1 gene cause early onset PD with autosomal recessive inhertiance. |
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Formal Description Interaction-ID: 8340 |
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| Drugbank entries | Show/Hide entries for PARK7 |